NECROTIZING VASC...

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Circulatory system

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Definition

Necrotizing vasculitis is a rare condition that involves inflammation of the blood vessel walls.

Alternative Names

Vasculitis - necrotizing

Causes, incidence, and risk factors

Necrotizing vasculitis is common with:

• Polyarteritis nodosa
• Rheumatoid arthritis
• Scleroderma
• Systemic lupus erythematosus
• Wegener's granulomatosis

It is very rare in children.

The cause of the inflammation is unknown. It is likely related to autoimmune factors. The wall of the blood vessel may scar and thicken, or die (become necrotic). The blood vessel may close, interrupting blood flow to the tissues it supplies. The lack of blood flow will cause the tissues to die.

Necrotizing vasculitis may affect any blood vessel in the body. Therefore, it can cause problems with the skin or any of the body's organs.

Symptoms

Fever, chills, fatigue, or weight loss may be the only symptoms at first. However, symptoms may be in almost any part of the body.

Skin:

• Abnormal skin tissue (lesions)
  • Papules (small, solid, and raised lesions)
  • Red or purple colored
  • Located on the legs, hands, or other parts of the body
• Fingers that change color (blue fingers or toes)
• Tissue death due to lack of oxygen
  • Pain or tenderness in the area
  • Skin redness
  • Sores (ulcers) that do not heal

Muscles and joints:

• Joint pain
• Leg pain
• Muscle contractions
• Wasting away of muscles

Brain and nervous system:

• Pain, numbness, tingling in an arm, leg, or other body area
• Weakness of an arm, leg, or other body area
• Pupils that are different sizes
• Eyelid drooping
• Swallowing difficulty
• Speech impairment
• Movement difficulty

Other symptoms include:

• Abdominal pain
• Blood in the urine or stools
• Painful menstruation
• Hoarseness or changing voice
• Symptoms related to damage of the arteries that supply the heart (coronary arteries)

Signs and tests

The doctor will perform a physical exam. A nervous system (neurological) examination may show signs of nerve damage.

Tests that may be done include:

• Biopsy of the muscle, organ, tissue, or nerve biopsy
• Chest x-ray
• Sedimentation rate
• Urinalysis
• Hepatitis blood test
• Blood test for antibodies against neutrophils (ANCA antibodies)

Reviewer Info: Mark James Borigini, Associate Clinical Professor of Medicine, University of California, Irvine, Irvine, CA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc., 05/31/2009